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Main session: Low molecular weight drug discovery and characterization



DiPIA: Profiling of compound kinetics in hit-to-lead drug discovery: EED as a case study

Sanjay Panchal of AbbVie presents.

42:13

DiPIA: Profiling of compound kinetics in hit-to-lead drug discovery: EED as a case study 42:13
DiPIA: Identification of novel small molecule inhibitors against NS2BN/N53 from Zika virus 16:58
DiPIA: Highly sensitive binding kinetics of CDK7/cyclin H by small molecules 29:02
DiPIA: Probing molecular mechanisms of metabolic enzymes using A-B-A injection method 29:51
DiPIA: SPR, beyond affinity and kinetics 38:10

 

Main session: Characterization of biotherapeutics



DiPIA: Displacement of BMP9 prodomains after receptor binding - discovered via SPR

Ute Jucknischke of Roche Diagnostics, GmbH, presents.

36:50

DiPIA: Displacement of BMP9 prodomains after receptor binding - discovered via SPR 36:50
DiPIA: Glycosylation profiling of biotherapeutics using lectin binding on Biacore 38:34
DiPIA: SPR informs selection of lead therapeutic candidates with desirable binding properties 31:13

 

Main session: Assessment of critical quality attributes of biotherapeutics



DiPIA: SPR in early discovery and characterization of vaccine antigens

Sumana Chandramouli of GSK Vaccines presents.

35:24

DiPIA: SPR in early discovery and characterization of vaccine antigens 35:24
DiPIA: SPR for biopharmaceutical drug release and stability testing 33:25
DiPIA: The importance of RMAX for activity assessment 37:59

 

Workshops: SPR-based assays for comparability and potency assessment



DiPIA 2018 Workshop: A new magnifying glass for CQA monitoring

Giordana Bruni of Merck Serono presents on the topic: A new magnifying glass for CQA monitoring.

24:46

DiPIA 2018 Workshop: A new magnifying glass for CQA monitoring 24:46
DiPIA 2018 Workshop: Ligand binding for assessment of similarity and relative potency 30:37
DiPIA 2018 Workshop: Fc receptors and their binding properties 19:26

 

Workshop: Use of SPR in process development of biotherapeutics



DiPIA 2018 Workshop: Early-stage SPR assays for recombinant subunit vaccine discovery

Markus Sack of Pro-SPR GmbH presents on the topic: Early-stage SPR assays for recombinant subunit vaccine discovery and process development.

30:28

DiPIA 2018 Workshop: Early-stage SPR assays for recombinant subunit vaccine discovery 30:28
DiPIA 2018 Workshop: Biacore Adenovirus quantification 29:23

 

Workshop: Driving forward drug discovery with binding kinetics



DiPIA 2018 Workshop: Optimization focused on target residence time results

Joost Uitdehaag of Netherlands Translational Research Center presents on the topic: Optimization focused on target residence time results in TTK inhibitors with potent anti-proliferative activity.

23:21

DiPIA 2018 Workshop: Optimization focused on target residence time results 23:21
DiPIA 2018 Workshop: Driving forward drug discovery with binding kinetics 31:43

 

Workshop: Small molecules as therapeutics: from structure-activity relationship to clinical trials



DiPIA 2018 Workshop: A small molecule strategy that disrupts a protein:protein interaction

Janice Villali of Sanofi Genzyme presents on the topic: Developing a SPR strategy for small molecules that disrupt a protein:protein interaction.

23:05

DiPIA 2018 Workshop: A small molecule strategy that disrupts a protein:protein interaction 23:05
DiPIA 2018 Workshop: Binding kinetics - a key parameter for rational drug design 24:39
DiPIA 2018 Workshop: SPR in late stage pre-clinical development 33:35

 

Tutorials



DiPIA 2018 Tutorial: Good, bad, or ugly? Understanding what the data is telling you

Cytiva's Michael Murphy and Paul Belcher provide insight into how to read the data.

56:16

DiPIA 2018 Tutorial: Good, bad, or ugly? Understanding what the data is telling you 56:16
DiPIA 2018 Tutorial: Current data analysis approaches 57:11
DiPIA 2018 Tutorial: Best practices for working with low molecular weight compounds 59:31
DiPIA 2018 Tutorial: Choosing the appropriate immobilization strategy 1:08:53

 

Posters