Mixing system: Wand Mixer
Mixing biocontainer: 200 L mixer biocontainer
Application mixing type: Powder-liquid
The Wand Mixer is a compact and noninvasive single-use mixing system. The heart of this system is a mixing biocontainer incorporating an innovative top-mounted impeller capable of providing efficient mixing for powder-liquid and liquid-liquid mixing applications. The impeller comprises a rotating wand inside an inert polymer sleeve, and is designed to ensure low particle shedding and total containment while serving effectively in a wide variety of mixing tasks.
Introduction
Powder-liquid mixing is a common requirement in biopharmaceutical processing. In order to optimize mixing efficiency for powder-liquid applications, the Wand Mixer is available with a large, diagonally mounted helical mixing wand.
In this experiment, a Wand Mixer was used to prepare 200 L of a concentrated salt solution.
Experimental
A 200 L Wand Mixer mixing biocontainer was filled with 200 L of water, and mixing speed was set to 250 rpm. A single 1.6 kg addition of sodium chloride (NaCl) powder was made to the mixing biocontainer, resulting in an 8 g/L solution. The solution homogeneity was monitored via real-time conductivity readings.
Results
Figure 1 shows solution homogeneity in the biocontainer during mixing.
After the NaCl powder addition, mixing was found to be 95% complete within approximately 90 s, and 100% complete within approximately 4 min.
Fig 1. Solution homogeneity in the biocontainer during mixing.
Conclusions
The Wand Mixer is well suited for preparation of concentrated buffer salt solutions. A powder-liquid mixing biocontainer, which includes a top-mounted wand impeller, is a good choice for such applications.
Mixing times in the 90 to 240 s range are typical at the tested volume and salt concentration.
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