With use of baculovirus expression vector systems (BEVS), more researchers are culturing insect cells. HyClone insect cell screened Fetal Bovine Serum (FBS) is based on our highest-quality Defined FBS. The serum is screened to identify lots that offer excellent performance with BEVS. This screening involves comparing cell yield and viability using insect cells grown in various test lots for four passages. These test lots are compared with a control lot that has demonstrated the ability to support robust growth of insect cells.

Data shows that 40 nm filtration will remove as many as eight logs of viral challenge. Studies demonstrate that this filtration regimen has no adverse effect on cell growth. Before dispensing, each lot of serum is pooled using true pool technology to ensure uniformity and consistency between bottles. Defined FBS has over 50 components analyzed on the finished product and the results are included in the certificate of analysis and the biochemical assay list.

Additional treatments available including heat-inactivation and irradiation. Additional testing, including EMEA-conforming testing, is also available.