HyClone Tetracycline Screened Fetal Bovine Serum (FBS) is designed for researchers using tetracycline-regulated gene expression systems in cultured cells. These systems rely on the presence or absence of tetracycline in the growth medium to either turn off or turn on gene expression. The presence of tetracycline in the serum might interfere with such systems. To eliminate the possibility of interference, the tetracycline content of several high-quality Defined FBS lots is determined by ELISA. The lots with undetectable tetracycline levels are selected as Tetracycline Screened FBS.

Data shows that 40 nm filtration will remove as many as eight logs of viral challenge. Studies demonstrate that this filtration regimen has no adverse effect on cell growth. Before dispensing, each lot of serum is pooled using true pool technology to ensure uniformity and consistency between bottles. Defined FBS has over 50 components analyzed on the finished product and the results are included in the certificate of analysis and the biochemical assay list.

Additional treatments available including heat-inactivation and irradiation. Additional testing, including EMEA-conforming testing, is also available.