• Bed height (cm)
• Total porosity, ε_tot
• Interstitial porosity, ε_interstitial
• Ionic capacity, Λ, column specific (in μmol/mL resin backbone)
• Bed volume (mL)
• Bead radius (µm)
• Specific adsorber surface area (m^-1)
• Ligand density (µmol/m^²)

f(x) columns give you confidence about the column parameters used for your model (including colloidal particle adsorption (CPA) model), and free up your time to focus on generating molecule-specific data. They are a good complement to GoSilico™ Chromatography Modeling Software.

A suitable column format for your process development work

Tricorn™ columns are high-quality, prepacked columns for robust and reproducible process development and validation. Because of the narrow 10 mm inner diameter combined with 20 cm or 10 cm bed height typically used in biomanufacturing, these columns are especially suited to scale-down studies.

About mechanistic modeling in chromatography

Mechanistic models use computer simulations to decrease the number of experiments needed during process development, and increase the design space investigated. These simulations are based on known physiochemical phenomena involved in chromatography and offer you the following advantages:

• Cost reduction and time saving — more data obtained from fewer experiments, which accelerates your process development.
• Improved robustness and efficiency to fulfill regulatory demands on quality by design.

Learn more about mechanistic modeling.