ÄKTA ready XL single-use chromatography system designed for manufacturing scale
- High capacity in a compact format.
- Flexibility supporting use in multiproduct facilities.
- Reliability suitable for GMP production.
To meet the capacity demands from single-use upstream processes (2000 L high-titer feeds), ÄKTA ready XL operates large-scale columns (up to 1200 mm), using the two flow kit sizes that cover a broad range of flow rates from 45 to 3500 L/h. The single-use flow path minimizes the need for cleaning and cleaning validation, allowing for quick changeover between productions, while eliminating the risk of carryover. ÄKTA ready XL offers the accuracy and documentation required for use in a GMP-regulated environment.
Compare our single-use chromatography systems
Suited for large-scale single-use manufacturing
ÄKTA ready XL provides high flow capacity, making the system well suited for purification of high-titer entities or for products produced in large-volume bioreactor cultures. The small system footprint enables an efficient facility use. Single-use sensors with high accuracy allows for reliable monitoring and control of the purification process. ÄKTA ready XL is controlled from an industrial computer installed with the UNICORN system control software. Using a standard for open platform communication (OPC), the interface is compatible with third-party system control software.
Flexible use in a broad range of applications
ÄKTA ready XL can be used for both isocratic and gradient elution. An ergonomic system design makes flow kit installation easy, and is quickly performed using the software-aided installation wizard. An installation test ensures proper connection of the sensors before start of the purification process.
Part of a scalable single-use chromatography platform
ÄKTA ready XL is preferably used with ReadyToProcess disposable columns with inner diameters of up to 450 mm. The system can also operate AxiChrom clean-and reuse columns with inner diameters of up to 1200 mm. For design of a disposable production line from upstream to downstream, ÄKTA ready XL and ReadyToProcess columns can be used with Xcellerex XDR single-use bioreactor systems, covering working volumes in the range from 10 to 2000 L, as well as Xcellerex XDM and XDUO single-use mixing.
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