MabSelect™ VL protein L resin in HiScreen™ chromatography columns. A redesigned protein L ligand captures antibody Fabs, bispecifics, and other variants containing a kappa light chain with high binding capacity and improved alkaline stability.
- High dynamic binding capacity for efficient capture of target molecules.
- Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents.
- Provides good resolution for product-related impurities in the capture of bispecific antibodies.
Built for a diversifying pipeline
As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.Read more
Redesigned protein L ligand
MabSelect™ VL protein L resin showed a two-fold increase in binding capacity compared to our Capto™ L chromatography resin. This higher capacity provides productivity advantages in research and biomanufacturing.
The MabSelect™ VL protein L resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand.
HiScreen™ columns are convenient for method optimization and parameter screening enabled by the 10 cm bed height for efficient chromatography process development. MabSelect™ VL protein L resin is also available in 1 mL and 5 mL HiTrap™ prepacked columns, bulk resins in different pack sizes, PreDictor™ RoboColumn® minicolumns, and ReadyToProcess™ columns for purifying protein as well as screening and process evaluation. Contact your Cytiva sales representative for more information.
Learn more about capture of bispecific antibodies and removal of product-related impurities using MabSelect™ VL resin.Read less
|17542015||HiScreen™ MabSelect™ VL||1 × 4.7 mL||1,329.00 USD||
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