HiTrap™ chromatography columns with MabSelect™ VL protein L resin. A redesigned protein L ligand captures antibody Fabs, bispecifics, and other variants containing a kappa light chain with high binding capacity and improved alkaline stability.

  • High dynamic binding capacity for efficient capture of target molecules.
  • Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents.
  • Provides good resolution for product-related impurities in the capture of bispecific antibodies.

Built for a diversifying pipeline

As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.

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Product Product Name Price
17542052 HiTrap™ MabSelect™ VL 5 × 1 mL 5 × 1 mL 779.00 USD Add to cart

In Stock Stock on request Limited stock

17542051 HiTrap™ MabSelect™ VL 1 × 1 mL 1 × 1 mL 199.00 USD Add to cart

In Stock Stock on request Limited stock

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