HiTrap MabSelect Xtra columns are prepacked with MabSelect Xtra, a BioProcess resin for capture of monoclonal antbodies from large sample volumes. The increased capacity of the resin is well suited for purification of Mabs from high-level expression feedstock.

• Increased dynamic binding capacity with smaller particle size and greater porosity than MabSelect resin.
• MabSelect Xtra uses the same recombinant protein A ligand as MabSelect
• Oriented coupling of recombinant Protein A to the matrix via an engineered C-terminal cysteine enhances IgG binding capacity.
• Fewer regulatory concerns due to the total absence of mammalian culture in the ligand production and purification.
• Prepacked HiTrap columns for process development, screening of purification conditions, and small-scale purification of Mabs.