Prepacked ReadyToProcess™ columns with MabSelect™ VL protein L resin. The redesigned protein L ligand provides high binding capacity and improved alkaline stability. For affinity capture of antibody Fabs, bispecifics, and other variants containing a kappa light chain. MabSelect™ VL in ReadyToProcess™ columns is supplied made to order in 80 mm, 126 mm, 178 mm, 251 mm, 359 mm, and 450 mm column diameter sizes in different bed heights.
- High dynamic binding capacity protein L resin for efficient capture of antibody Fabs, bispecifics, and variants containing a kappa light chain.
- Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents.
- Provides good resolution for product-related impurities in the capture of bispecific antibodies.
- ReadyToProcess™ columns with robust design and validated column packing methods for consistent performance.
Built for a diversifying pipeline
As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.Read more
Redesigned protein L ligand
MabSelect™ VL resin showed a two-fold increase in binding capacity compared to our Capto™ L chromatography resin. This higher capacity provides productivity advantages in research and biomanufacturing.
MabSelect™ VL resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand.
Convenience and versatility of ReadyToProcess™ chromatography columns
ReadyToProcess™ columns provide a robust design and validated column packing methods for consistent performance. Reduce cost by eliminating the need for column packing, preparation, and validation procedures.
ReadyToProcess™ columns fulfil industrial demands for security of supply, robust performance, and regulatory support.
MabSelect™ VL protein L resin is also available in 1 mL and 5 mL HiTrap™ prepacked columns for research applications and as bulk resins. Contact your Cytiva sales representative for more information.Read less
|17542066||ReadyToProcess™ MabSelect™ VL NS, 32 L (450/200)||32 L||On Request||
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