VIIISelect is an affinity resin designed for the purification of recombinant β-domain-deleted factor VIII, a key recombinant blood factor used for treatment of Hemophilia A. Due to the sensitive nature of the factor VIII molecule, it is important to limit the number of steps in the downstream process. The high selectivity and yields obtained using VIIISelect enable a robust and efficient purification process with excellent purity obtained in one step.