Enables a two-step chromatographic process

The resin is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The strong multimodal ligand gives a different selectivity compared with traditional ion exchangers. Capto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Together with a Protein A capture step, like MabSelect SuRe, Capto adhere allows the design of a two-step chromatographic process for mAbs. For optimized performance of Capto adhere, screening and optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor 96-well filter plates.

Key benefits of ReadyToProcess columns include:

• Robust column design and validated packing methods enable consistent column performance.
• Standardized column formats allow reduced column cost and off-the-shelf availability for short delivery lead times.
• Cost-savings by eliminating the need for column preparation, packing, and validation procedures.
• Fulfills industrial demands for security of supply, robust performance, and regulatory support.