Designed to select for small-fragment cfDNA while minimizing genomic DNA contamination, Sera-Xtracta Cell-Free DNA Kit offers reliable extraction and purification of cfDNA for liquid biopsy from samples including plasma, serum and urine. High yield and sensitivity make the kit well-suited for applications such as cancer diagnosis and monitoring, even when sample is limited.

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Read application note: Detection of cancer-associated mutations in plasma from stage IV Non-small cell lung cancer (NSCLC) patient samples

Read application note: Targeted NGS biomarker discovery using serum from stage IV non-small cell lung cancer (NSCLC) and colorectal cancer (CLC) patient samples

Read application note: Plasma based-monitoring of therapeutic response and resistance in patients positive for epidermal growth factor receptor (EGFR) biomarker

• Efficient recovery of small-fragment cfDNA in the size range 50-300 bp: capture more cfDNA to increase sensitivity levels.
• Minimal co-purification of higher molecular weight genomic DNA due to active selection of smaller fragments which improves sensitivity in downstream applications.
• Scalability: one kit to cover up to 4 mL input of sample.
• Efficient extraction: procedure can be completed in 120 minutes.
• Ease of use: compatible with molecular biology techniques, including next-generation sequencing (NGS), qPCR, ddPCR, BEAMing and other amplification and genotyping applications.