Biacore Insight Concentration and Potency Extension

Biacore Insight Concentration and Potency Extension provides concentration analysis, parallel line analysis (PLA), and EC50 evaluation to Biacore Insight Evaluation Software. For Biacore 8K+, Biacore 8K, Biacore T200 and Biacore S200 SPR systems.

Determine active protein concentration with confidence, shorten time to results with automation, and minimize hands-on time.
Increase assay precision and reproducibility over a wide dynamic range.
Reliably determine drug product amount and activity using surrogate potency assays, which reduces costs and saves time.
Eliminate errors in data transfer with built-in PLA tool.

Confident concentration analysis

The software enables measurement of the biologically active concentration of drug candidates using surface plasmon resonance. Highly reproducible data is generated over a wide dynamic range with a coefficient of variation typically below 5%.

Generate calibration curves with ease

The precision and automation of the software reduces hands-on time and supports both parallel and serial run modes. Calibration curves may be generated using four-parameter or linear-fitting models. The software supports evaluation of the samples using single and average calibration curves.

For long runs in serial mode, interpolation of calibration curves to compensate for drifts in the assay may be performed to generate highly reliable data. Control samples may be included to allow you to ensure rigorous quality control of your assay.

Select from EC50 and PLA drug potency analyses

Potency analyses are performed using PLA or half-maximal response (EC50) determinations. The PLA functionality makes the assessment of potency based on a linear fit to the linear part of the response vs logarithmic concentration assuming a common slope. The EC50 determination is based on a four-parameter equation being fitted to the response vs concentration.

Floating e-licensing for greater flexibility

Biacore Insight Evaluation Software and extensions introduce floating licenses to allow sharing of access rights between users and computers. Electronically secure a machine license for one computer, or a concurrent license for networks. Time-limited licenses let you scale the number of licenses needed for more flexibility.