Good column packing is essential for any chromatographic process and plays a key role in the large-scale commercial manufacture of biopharmaceuticals. Robust and verified packing and testing methods help eliminate concerns and risks associated with poorly packed beds.
There is more to chromatography than the column. The ÄKTA systems support our columns throughout scales. Easy buffer management can also be integrated to the process. Different levels of automation are available through UNICORN software and DeltaV™ Distributed Control System.
“Within a month or two of bringing the new columns in, we were able to qualify everything, pack them and get them into service. That was a huge advantage to us.”
Principal Process Specialist, manufacturing a prescription medication for chronic conditions, US
Manufacturing biopharmaceuticals demands very high hygiene standards. Minimizing manual handling through closed systems is one way to address this. Sanitization is another important consideration. For chromatography, success will depend on column design and the power of the sanitizing solutions.
Reproducibility is essential as your process moves from process development to full-scale manufacturing. A scalable column platform will help meet this challenge.
