Breakthrough buffer bottlenecks

In downstream purification, buffer storage and buffer preparation often take up lots of time and facility space. This can make scale-up difficult, especially when space is limited. Buffer management strategies like inline conditioning (IC), inline dilution, and using ready-made buffers can help.

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Large-scale buffer preparation

See how to reduce buffer volumes up to 79% and floor footprint by 40% for buffer production.

Video playlist on buffer management topics

Access our YouTube playlist

Explore buffer solutions from Cytiva.

Buffer volumes handled per batch for different buffer preparation methods.

Efficient buffer blending

Save time and labor using the Inline dilution feature on AKTA process chromatography system.

Buffer management webinar

Mastering buffer management

Watch on-demand: Intensify your buffer strategy with our tips. Includes customer case study.

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HyClone™ buffers and process liquids

Premade and buffer concentrates for hydration, handling and purification of biologics.

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BioProcess™ IC System

For automated buffer management with inline conditioning.

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ÄKTA process™ chromatography system

Optional third pump provides automated inline dilution functionality.

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ÄKTA avant™ chromatography system

Prepare and screen buffers for pH and conductivity conditions using BufferPro feature.

Explore more ways to intensify your process

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Upstream process intensification

Maximize cell culture productivity and intensify your upstream process.

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Downstream process intensification

Explore how to implement intensified strategies for downstream processes.

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Process intensification hub

Still exploring? Start here in our process intensification hub.

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Process intensifier app

Use your own process data to explore different process intensification strategies

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Process intensification e-Learning

In this course, learn techniques and strategies to help you improve and optimize your upstream and downstream biopharmaceutical production processes.

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Process Intensification Webinar Hub

From cell culture to downstream, explore process intensification webinars.

  • Other resources

  • Efficient and scalable buffer preparation
  • Connected inline conditioning for better process efficiency
  • Buffer quality and inline conditioning
  • Can a machine make buffers?
  • Journal articles

  • Automated buffer preparation – Increasing production capacity while maintaining footprint
  • Automated buffer production for cGMP use
  • Traditional versus automated buffer preparation methods
  • Underrated yet critical buffer management
  • How effective buffer management facilities biopharmaceutical production
  • Training and education

  • Get to know: process intensification
  • Inline conditioning control modes
  • How an inline conditioning system works