DNA fragmentation is the separation or breaking apart of DNA strands into smaller pieces. DNA fragmentation can occur naturally or intentionally in laboratories.
Fragmentation of DNA or nucleic acid for genomics studies can be done in several ways: chemical methods, such as enzymatic fragmentation; mechanical methods, such as sonication; and methods using heat.
Separation of DNA strands into smaller pieces. Can occur naturally or intentionally in laboratories.
Due to the average fragment length requirements of most sequencing platforms available today, DNA and RNA fragmentation becomes a necessary step in sample preparation for achieving high sensitivity and unbiased results. For this reason, it is crucial to carefully choose the most appropriate fragmentation method.