No. Silicone does not melt and is a thermoset, so it is not possible to seal silicone tubing. Consider using C-Flex® which has many of the same properties but can be sealed and also joined in our Sterile Tube Fuser. PTFE tubing cannot be sealed either, due to its thermoset material properties.
Inspecting seal quality
The HOT LIPS TUBE SEALER is designed to make reproducible and reliable seals, however it is still critical to inspect the seal prior to use. Check that the correct tubing type and diameter are set as in many cases a poor seal is the result of using the wrong tubing program.
Note: Allow the seal to cool for 2 to 3 minutes before inspection to achieve optimal strength.
Check that the seal has smooth and uniform edges. There should be no splitting or cracking.
The seal should have uniform width. Check that the plastic has melted through and that the seal is homogeneous. If the seal is wider on top, then it was not centered properly in the sealer jaws.
There should be no bubbles or cracks in the center portion of the seal.
Since the inner part of the tubing is never exposed there is no issue of contamination during the sealing operation. Validation should consist of evaluating reproducibility and seal strength to ensure consistent performance of the tube and tube contents to be used in the GMP process.