Capto™ adhere ImpRes multimodal chromatography resin
This multimodal, strong anion exchange resin supports effective mAb polishing in the second or third step of a purification scheme downstream of the protein A capture step.
Pack size
Overview
- High yields achieved through the high-resolution beads and selectivity of the ligand.
- Efficient removal of aggregates, viruses, and main contaminants in mAb processes.
- Enables use of a platform approach to mAb process development.
- Allows separation of mAb charged variants.
- Resin fulfills industrial demands for security of supply, robust performance, and regulatory support
Helps solve purification problems
The multimodal anion exchanger ligand of Capto adhere ImpRes is immobilized to the base matrix and interacts with the target molecule through multiple types of interactions.
The high selectivity of the anion multimodal ligand allows operation in a variety of process conditions to solve challenging purification problems. Contaminants such as DNA, host cell proteins, leached protein A, aggregates, and viruses are efficiently removed.
Prepacked columns and other formats
Capto adhere ImpRes resin is available in the following formats:
Process development scale: prepacked
- PreDictor Capto adhere ImpRes filter plates, 96-well plates for high-throughput screening or process development.
- PreDictor Capto adhere ImpRes RoboColumn™ units, miniaturized columns for high-throughput process development.
- HiScreen Capto adhere ImpRes columns, optimized for method and process development.
- f(x) column, prepacked and precharacterized chromatography column for fast and accurate mechanistic modeling
Lab scale: prepacked for manual purification
HiTrap Capto adhere ImpRes columns, for easy use with a syringe, peristaltic pump, or chromatography system.
Lab scale: prepacked for automated purification and analysis
HiTrap Capto adhere ImpRes columns, for easy use with a syringe, peristaltic pump, or chromatography system.
Process characterization: resin kits
Process Characterization Kit Capto adhere ImpRes, designed for studying the potential impact that resin ligand density might have on the process outcome.
Process-scale purification: prepacked
ReadyToProcess Capto adhere ImpRes columns, 1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.
