Process-scale column packing

To make sure the purification process and the final product are robust and secure, packed columns need to be properly prepared and qualified. Column efficiency testing and slurry and buffer preparation, regardless of scale, are vital in this process.

Techniques for column packing have evolved. Historically, column packing was a manual process, using techniques like pack-in-place and constant flow. To meet the needs of bioprocess scale-up, technology has advanced. Axial compression supports situations requiring rapid, highly reproducible packing, and is used in AxiChrom, our automated column packing platform.

Reproducibility is essential as your process moves from process development to full-scale manufacturing. When scaling, there are several aspects to consider. A scalable column platform will help. Using column volume per hour instead of constant bed height can be an alternative option.