Xcellerex APS intensified seed culture for a fed-batch process

Process we developed produced 179 MVC/mL in a 50 L bioreactor.

Xcellerex X-platform and perfusion cell culture

Scalable perfusion cell culture using Xcellerex™ X-platform single-use bioreactors

Learn how Xcellerex™ X-platform single-use bioreactors perform scalable, robust perfusion cell cultivation processes

Intensifying your fed-batch process using cryobags

In this article we compare conventional seed train methods to the use of high-density cryobags. We show that high-density cryobags can be used too.

Running steady state perfusion with WAVE bioreactors

Steady-state perfusion using ReadyToProcess WAVE™ 25 rocker

Learn how to successfully run steady-state perfusion in a rocking bioreactor for 18 days.

Using perfusion to intensify seed train operations

Concentrated fed-batch

Intensify your process by going from cell vial to 2000L bioreactor in 1 step.

Cell culture media optimisation for perfusion

A small-scale model to increase yield in cell culture perfusion of a mAb at large scale

Small-scale model for a monoclonal antibody (mAb) cell culture perfusion.

Steady state perfusion with Xcellerex APS

Large-scale perfusion cell culture

We have successfully conducted a large-scale perfusion run using Xcellerex APS connected to an Xcellerex XDR 50 bioreactor.

Perfusion is vital for increasing productivity in upstream bioprocessing

Designed to address your needs for flexibility, reliability, and simplicity in upstream perfusion applications, the Xcellerex Automated Perfusion System (APS) is a single-use system for both process development and production. You can read more about the Xcellerex APS in this data file.

Xcellerex Automated Perfusion System with XDR 50 system

Intensified fed-batch process

The fed-batch process is the workhorse of recombinant protein production. Traditionally, the seed train for fed-batch processes is operated in batch mode. Introducing perfusion in the seed train can increase productivity and alleviate bottlenecks.

Explore more ways to intensify your process

Downstream process intensification

Explore how to implement intensified strategies for downstream processes.

Process intensification for buffer management

Buffer management strategies save time, space and costs in bioprocessing.

Process intensification hub

Still exploring? Start here in our process intensification hub.

Process intensifier app

Use your own process data to explore different process intensification strategies

See how Xcellerex Automated Perfusion System (APS) can make cGMP manufacturing of preclinical and clinical material more productive. APS integration is a seamless way to Xcellerex bioreactors and switches filters automatically. Use this versatile alternative to ATP perfusion for both process development and production.

See it in 3D

Download data file

Stirred tank bioreactor systems

Scalable single-use bioreactor platforms with up to 5:1 turndown.

Rocking bioreactors

Single-use rocking bioreactor systems for process development

Perfusion systems

Automated perfusion systems increase yields and ensure consistent production.

Cell culture media and feeds

Choose from chemically defined, animal component-free and classical cell culture media.