Cell expansion

Expansion in cell processing

During cell expansion, it is important to reach target cell density as quickly as possible, without affecting phenotype or function. Effective use of automation, paired with functionally closed systems and high-quality reagents, can help you drive reliable cell expansion that meets these criteria.

General cell processing workflow with expansion highlighted

Forget the flask

Manual cell expansion methods are variable, especially when multiple operators are involved. Manual operations are also inefficient, with many handling steps that risk sample loss. Automation can improve efficiency and yield. It can also enhance speed and reproducibility. As part of an optimized workflow, connect Cytiva and third-party equipment using Chronicle automation software to enable fully integrated cell processing.

Reliable automation that scales

For a reliable approach that is consistent with good manufacturing practices (GMP), consider the Xuri Cell Expansion System W25. Cells are cultured in functionally closed Cellbag bioreactors that are subjected to controlled rocking and perfusion. Single-use Cellbag technology can then help you scale out to meet parallel expansion demands as you progress to clinical trials and beyond.

SEE XURI W25 IN ACTION

Robust perfusion medium

Careful choice of a perfusion medium yields high viable cell densities despite donor variability. You can achieve this outcome with Xuri T Cell Expansion Medium. This medium follows USP<1043> for ex vivo cultivation. It is chemically defined and free from any human or animal-derived components. The single-use bag container allows easy connection to a Cellbag bioreactor in a Xuri system, so you can manage contamination risk.

Well-characterized growth factors

To achieve consistent results in research, process development, and manufacturing, opt for growth factors with well-characterized biological activity. Xuri growth factors are manufactured, tested, and released in compliance with relevant cGMP guidelines. Xuri IL-2, Xuri IL-15, and Xuri IL-21 are consistently manufactured to reduce the need for revalidation when you get a new batch.

Manage risk and protect cell quality with automated and functionally closed systems. Use with rigorously tested density gradient media or magnetic beads.

Improve process efficiency with an automated, simple, and functionally closed system.

Simplify workflows by automatically sequencing multiple steps. Functionally closed processing helps you manage contamination risk.

Preserve cell viability and function with automated dry freezers and thawers. Connect units across sites and monitor remotely using platform software.