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Vector manufacturing platforms and facilities

Rapidly add capacity and retain flexibility with modular end-to-end options

  • BSL-2 manufacturing facilities

    Rapidly add viral vector production capacity with expandable end-to-end solutions. KUBio and KUBio box include single-use processing lines, integrated automation, and proven processing support and expertise.

  • Single-use platforms

    Optimize upstream and downstream efficiency while reducing operational costs. Configure FlexFactory platforms to meet specific process requirements, and easily scale up or out as your requirements change.

  • Other gene therapy solutions

    Products, case studies, and support for process development and manufacturing of plasmids and vectors.

A flexible collaboration

Enterprise Solutions has many interconnected elements that flex to match organizational needs. Let us collaborate to identify the right vector production solution for you now, with an eye toward the future.

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PD and manufacturing services

If you are looking to develop an robust, scalable gene therapy vector manufacturing process, our Fast Trak PD teams are ready to support your project. To help maintain your timelines, we can also make your AAV and LV vector. This can be done in parallel to any process development work or capacity expansion efforts. The gene therapy vectors produced by the Fast Trak PD team are suitable for preclinical through early clinical studies. Image credit: CCRM

Interested in services for other viral vectors such as adenovirus?

End-to-end manufacturing

Efficient adeno-associated virus (AAV) and lentivirus (LV) production maximizes recovery at each step while maintaining viral function and stability. Achieve these goals with FlexFactory single-use platforms across upstream and downstream processing. Configure FlexFactory to meet specific process requirements, and easily scale up or out as your requirements change.

We also have FlexFactory for other viral vectors and biomolecules.

Upstream processing

Scalability is a key consideration for GMP manufacturing. Conventional static culture is prone to contamination and requires additional flasks to increase capacity. Scale upstream processing to 50 L and beyond by combining single-use components such as bioreactors, mixers, and connectors. This set-up also allows you to manage contamination risk by functionally closing operations.

Explore Xcellerex bioreactors and other upstream single-use technologies.

Downstream processing

Maintaining viral particle stability and infectivity are key downstream processing challenges. Purification must be gentle, with as few steps as practical to maximize titers while removing contaminants. Meet these needs by combining filtration with column chromatography.

See how Capto Core 700 with dual functionality streamlines adenovirus purification.

AAV vector collaboration

AAV vector collaboration

News: Cobra Biologics, GE, and Centre for Process Innovation collaborate to advance gene therapy. Innovate UK funding supports development of scalable, cost-effective AAV production.

China lab supports gene therapy

China lab supports gene therapy

Blog: A new lab in Shanghai is offering much-needed industrial support for cell and gene therapies. Process development, manufacturing, and training services in China.

Scalable virus production

Scalable virus production

Article: Read about this optimized adenovirus process from cell culture through purification. This process could potentially be used for purification of other viral vectors.

Contact us

We’re happy to answer any questions you have, or provide you with more info on the elements of Enterprise Solutions. Just send us a short note

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Related products

  • Xcellerex XDR platform – single-use, stirred-tank bioreactors for cell cultivation up to 2000 L
  • ReadyToProcess WAVE 25 bioreactor – single-use, rocking bioreactor for growing cells up to 25 L
  • HyClone media and reagents – for cell growth, transfection, and buffer preparation
  • Xcellerex mixers – single-use mixers for media and buffer preparation
  • Single-use bags and connectors – to make aseptic connections between single-use components
  • ULTA NFF filters – single-use capsules for harvest, clarification, and final filtration
  • ReadyToProcess TFF filters – single-use cartridges for concentration
  • ÄKTA tangential flow filtration systems – range of single-use filtration systems from benchtop to GMP production
  • ÄKTA chromatography systems – range of automated systems from benchtop to GMP production
  • Anion exchange resins and columns – for virus purification
  • ReadyToProcess Adsorber Q – single-use anion exchange membranes for virus purification
  • Capto Core 700 resin and columns – combines size exclusion and binding properties for lentivirus purification
  • Capto Core 400 resin and columns – for intermediate purification and polishing
  • Capto AVB resin and columns – affinity purification of AAV, with ligand derived from single-chain antibody
  • Heparin Sepharose – heparin-based affinity purification of AAV
  • Size exclusion resins and columns – for virus purification and analysis
  • Xcellerex XDR microbial system – single-use, stirred-tank fermentor for growing plasmid-containing microbial cultures
  • Capto PlasmidSelect resin and columns – to purify supercoiled plasmid DNA
  • Cytodex microcarriers – for growing adherent cells in suspension culture

Related content

  • Viral vector brochure
  • Collaboration on improving adeno-associated virus manufacturing
  • China lab supports cell and gene therapy with PD and other services
  • KUBio BSL-2 manufacturing facility
  • Going viral: How a new factory-in-a-box is helping scale up manufacturing of viral vector- based therapies to reach more patients
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