AAV vector production workflow

How to overcome AAV manufacturing challenges

Adeno-associated virus (AAV) vectors have emerged as a promising tool for gene therapy, holding tremendous potential to treat a wide array of genetic disorders. However, the journey from lab to commercial production has not been without obstacles. In this video, we'll explore valuable insights into challenges and triumphs of AAV manufacturing.

Gene therapy AAV vectors

Adeno-associated viral (AAV) vectors are a common delivery system for gene therapies with advantages including enhanced safety compared to other vectors. A variety of AAV serotypes target different tissues to support a variety of therapeutic applications, but they all share common manufacturing challenges and solutions.

Why AAV?

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Process development services

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Pioneer the new era with the right cell line

Prevalent indications are the next frontier for adeno-associated virus (AAV)-based gene therapy. Transient transfection is simple but not efficient or scalable enough. An ELEVECTA™ producer cell line contains all genes to produce rAAV; simply induce. The result is a simplified and robust upstream process that easily scales to treat hundreds of thousands.

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Let’s talk end-to-end, scalable solutions for AAV production

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Develop and refine your AAV production process

End-to-end scalable solutions for AAV production from cell lines through filling

How to overcome AAV manufacturing challenges

Robust and scalable AAV production

Adherent cell process

Suspension cell process

Effective AAV polishing

Gene therapy AAV vectors

Process development services

Pioneer the new era with the right cell line

iCELLis™ fixed-bed bioreactors

ÄKTA ready™ 450 single-use system

Capto™ Q resin

Capto™ AVB affinity resin

Let’s talk end-to-end, scalable solutions for AAV production

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