Optimize nucleic acid isolation in molecular biology applications

The effective capture of highly fragmented cfDNA and minimized co-purification of higher molecular weight DNA increases the probability of detecting mutations that constitute a minor proportion of genetic alterations present in the tumor. The Sera-Xtracta Cell-Free DNA Kit provides efficient extraction of the main cfDNA peak, reduction in gDNA carry-over, and increased recovery of small fragments.

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Recent years have seen the development and adaptation of several approaches to NGS sample preparation, aiming to improve speed, throughput, and reproducibility. Many of these approaches are also compatible with automation, providing the opportunity to minimize human error, variation and bottlenecks, and further improve consistency between samples from different batches.

DNA isolation (and RNA isolation) is the first step for many modern genomics techniques and applications, which require high-quality starting material free of contaminants. The choice of approach depends on several factors, including the target DNA, source organism, the type and quality of starting material, and the application. This guide suggests products and solutions for optimizing the steps in the nucleic acid isolation process.