High throughput process development in biopharma

Why use high-throughput process development?

Efficient development of the manufacturing process is a crucial component of the overall biopharmaceutical development. During early process development, HTPD:

shortens development time
increases the amount of information available
enables reduction of sample amount used

Comparing time spent and sample used Predictor plate vs column

HTPD allows early screening of chromatography conditions

HTPD can be used for the initial screening of process conditions, or for a more thorough investigation of a defined space as a basis for detailed process understanding and/or robustness studies.

After scouting and screening, verification and optimization are performed with larger columns.

How to select the most suitable HTPD tool

The tools used in process development complement each other, as they deliver different types of data. Compare the various process development tools or select your product online by answering a series of simple questions.

Compare tools

Key takeaways from last HTPD conference

The goal of the HTPD conference has been to provide a leading forum for discussion and exchange of ideas surrounding the challenges and benefits of employing high-throughput techniques in the development of production processes for biological products.

Read articles providing takeaways from this conference:

Evolution of process development methodology

Parallel purification with PreDictor 96-well filter plates

Multiwell plates prefilled with resins (2, 6, 20, and 50 µL volumes), allowing parallel screening of chromatographic conditions. For manual or automated workflow.

Parallel purification with Predictor RoboColumn™ units

8 miniaturized columns prepacked with resins (50, 200, and 600 µL volumes), allowing parallel screening of chromatographic conditions. For automated workflow on robotic systems.

Rapid cycling with Fibro chromatography

With purification cycles in minutes rather than hours, throughput can be increased up to 20-fold compared to resins. Does not require specialized liquid handling equipment.

Tips and instructions for using HTPD tools

How to use PreDictor Plates:

How to use PreDictor RoboColumns:

Instruction for use

Related products

Click on the product of interest to access to the product page of the chosen product. Note that this list is not exhaustive. Additional prepacked PreDictor plates or RoboColumn are available, as standard offering, or customized for you.

Screening kits PreDictor

Protein A PreDictor plates, RoboColumns

Multimodal chromatography PreDictor plates and RoboColumns

HIC PreDictor plates and RoboColumns

IEX PreDictor plates and RoboColumns

Assist Software to support PreDictor plate workflow from set-up of experimental design to data evaluation

Assist Software 1.6

High-throughput process development (HTPD) in biopharma