Mixing system: Wand Mixer
Mixing biocontainer: 75 L Mixer biocontainer
Application mixing type: Powder-liquid
The Wand Mixer is a compact and non-invasive single-use mixing system. The heart of this system is a mixing biocontainer incorporating an innovative top-mounted impeller capable of providing efficient mixing for powder-liquid and liquid-liquid mixing applications.
The impeller comprises a rotating wand inside an inert polymer sleeve, and is designed to ensure low particle shedding and total containment while serving effectively in a wide variety of mixing tasks.
Introduction
Powder-liquid mixing is a common requirement in biopharmaceutical processing. In order to optimize mixing efficiency for powder-liquid applications, the Wand Mixer is available with a large, diagonally mounted helical mixing wand.
In this experiment, a Wand Mixer was used to prepare 75 L of a concentrated salt solution.
Materials and methods
A 75 L Wand Mixer mixing biocontainer was filled with water, and impeller speed was set to 150 rpm. A quantity of sodium chloride (NaCl) powder was added to the mixing biocontainer, and the solution homogeneity was monitored via real-time conductivity readings.
The entire experiment was repeated using an impeller speed of 200 rpm.
Results
Figure 1 shows solution homogeneity in the biocontainer during mixing; the plateau areas indicate steady state. Impeller speed had a modest but measurable impact on mixing times, which ranged from 10 min at 200 rpm up to 15 min at 150 rpm.
Fig 1. Shows solution homogeneity in the biocontainer during mixing.
Conclusions
The Wand Mixer is well suited to preparation of concentrated salt solutions. A powder-liquid mixing biocontainer, which includes a top-mounted wand impeller, is a good choice for such applications.
CY59907