Disposable bags

Single-use systems in bioprocessing

Single-use systems (SUSs) are used in upstream and downstream bioprocesses such as cell culture, filtration, purification, and filling. Single-use bioprocessing equipment includes liquid-handling bags, connectors, tubing, mixing bags, filters, or chromatography columns or units. These ready-to-use solutions come in varying designs and quantities to match specific applications and unit activities.

Single-use systems offer several advantages over stainless-steel and conventional systems for bioprocessing and manufacturing. Benefits of single-use assemblies can include:

• Reduced risk of contamination and leaks
• Less downtime for cleaning
• Improved water and energy efficiency
• Vendor documentation control and quality assurance
• Enhanced manufacturing flexibility

Often, manufacturers of single-use equipment offer a range of compatible or standardized components to make it easier to connect different parts of a process. The flexibility offered by standard single-use assemblies can be helpful where small batches of different products are made or where facility expansion or scale up are expected in the future.

Single-use process bags and assemblies

We offer 2-D and 3-D single-use bag assemblies to match your unique bioprocess requirements. Below is an overview of our single-use bag assemblies for small and large-scale applications.

ReadyCircuit™ 2-D hanging pillow bags

ReadyCircuit™ 2-D hanging pillow bag assemblies for small-scale applications come in 1, 5, 10, 20, and 50 L sizes. They facilitate the speedy assembly of various fluid-processing circuits. Equipped with single-use connectors, they support different ReadyCircuit™ process components. Their certified gamma-irradiated construction ensures no contaminants get into your process line.

With convenient port orientation, bag design, and supporting hardware, these 2-D hanging bags make it simple to fill and recover products. Some have an optional retentate port that facilitates efficient crossflow filtration mixing. Bags up to 20 L feature a needleless port that processes sample collection. Their single-ply 5-layer film is tear-resistant.

ReadyCircuit™ single-use 3-D bag assemblies

ReadyCircuit™ 3-D bag assemblies support large-scale bioprocessing applications of 50 L to 1000 L. They come with disposable single-use connectors for integration with a wide range of process components. These bags come in different capacities to enable straightforward scale-up. Pair them with accessories such as ReadyKart™ mobile processing stations for an optimized workflow.

Single-use assembly applications

Applications of ReadyCircuit™ 2-D and 3-D bags include:

• Cell culture seeding and expansion
• Filtration
• Fluid management for inline conditioning
• Cell culture media preparation

FAQs

Here are some commonly asked questions about single-use assemblies.

What are single-use assemblies?

Single-use assemblies are ready-to-use assemblies of components such as bags, connectors, and other fittings for use in bioprocessing applications such as fermentation, cell culture, filtration, or purification.

How are they used?

Researchers and biomanufacturers use single-use technology in different applications to ensure a sterile fluid flow of pharmaceutical products.

Common applications include:

• Storage or transportation of sterile solutions
• Chromatographic processes
• Containing products for irradiation or sterilization
• Cryopreservation
• Transferring solutions to bioreactors
• Cell culture and fermentation