ÄKTA ready™ chromatography systems are automated chromatography systems that use single-use flow kits and intuitive software for purification steps in GMP manufacturing.
No cleaning and validation needed Single-use flow path minimizes the need for cleaning validation, allowing for quick changeover between productions and reducing the risk of carryover. Fully disposable flow paths are quick to install and validate, improving productivity.
One platform takes you from bench to full-scale manufacturing Scalable platform for purification of monoclonal antibody (mAb) processes in a GMP-compatible environment. The systems are also ideal for production of sensitive biologics such as viral vectors, nucleic acids, and antibody-drug conjugates (ADC’s).
Meet today’s purification demands Each system has been designed with customer input for high performance and reliability. Pair the system with prepacked columns or membranes to handle demand from the upstream process and reduce batch turnaround time. Easily create and run methods with intuitive UNICORN™ software.
Closed-system operation Flow kits can be ordered with ReadyMate™ connectors or AseptiQuik™ aseptic connectors to maintain a closed flow path.
Training and regulatory support Keep your operators confident in operating the systems with our library of on-demand instruction videos and virtual training modules. Documentation, including extractables and leachables, for the flow kits, change control notifications and qualification services are available to meet regulatory demand.
Xcellerex™ XDUO mixer connected through PROFIBUS (extended)
Xcellerex™ XDUO mixer connected through PROFIBUS
Purification formats
Columns
ReadytoProcess™ columns from 8 cm to 600 cm inner diameter
Standard bed heights 15, 20 and 25 cm (custom bed heights from 10 to 24 cm)
AxiChrom™ columns 50 to 1200 mm inner diameter
Membranes
Mustang™ membranes in Acrodisc™ filters or Kleenpak™ capsules
0.86 to 5000 ml
The flow kits include a single-use pump head and tubing, with integrated sensors for pressure, conductivity, temperature, flow, UV, and pH (depending on the flow kit; see ordering information for details). Flow kits for ÄKTA ready 450 system are designed with a valve block to snap into place for each installation. For the other ÄKTA ready systems, order the required size flow kit for isocratic elution or add the gradient section for gradient elution.
UNICORN™ software provides intuitive and flexible method creation, system control, and process evaluation to simplify your purification workflows. Connecting flow kits is quick and easy and can be confirmed by an installation test within the software.
For users who require chromatography equipment to be used on their facility’s plant-wide automation platform, ÄKTA ready™ systems can be customized with a distributed control system or can connect to automation options via Open Platform Communications-Unified Architecture (OPC-UA). Visit the UNICORN™ software product page.
