Biacore 8S SPR system with open door and bottles

Biacore™ 8 series SPR systems

16 flowcell SPR platform for high-throughput screening and characterization: speed, scalability, sensitivity, and reliable performance, now and as drug discovery evolves.

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Biacore™ 8 series system

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Overview

Cytiva's Biacore™ 8 series SPR systems are engineered for demanding small‑molecule and biotherapeutic discovery. Deliver high‑quality affinity, kinetics, concentration, and yes/no binding data with enhanced capacity and sensitivity. Integrated plate handling for up to 12 plates eliminates the need for external automation, and provides seamless, precise results for confident decisions. Biacore™ 8 series systems are built for your needs in discovery today and the innovations of tomorrow.

Flex between high-throughput screening and high-quality molecular characterization, in one robust SPR platform, minimizing capital spend while maximizing efficiency.
Run hands-off with built-in automation, method queuing, and integrated plate handling of up to twelve 96- or 384-well microplates for 72 h.
Screen faster with streamlined workflows—run 384 proteins in 15 min.
Generate accurate kinetics across the full interaction spectrum, from the fastest to the slowest on- and off-rates.
Analyze fragments, low-abundance analytes, and sensitive targets.
Gain deeper insights from lower sample amounts with triple-parameter screening—concentration, kinetics, and epitope binning—in 66% less analysis time.
Save up to 80 % data analysis time with supervised machine learning software and integrate data seamlessly into your organization's data management system.
Transform complex molecular interactions into a robust and reliable comparability assessment with Sensorgram comparison.

Biacore™ 8 series SPR systems comparison

	Biacore™ 8S system	Biacore™ 8S+ system	Specification description and impact
Dissociation rate (k_d)	10^-6 to 0.5 s^-1	10^-6 to 0.5 s^-1	10^-6 to 1 s^-1 allows you to reliably determine molecules with very fast and slow off-rates.
Short term noise (RU(RMS))	Typically < 0.01	Typically < 0.01	Value < 0.01 allows you to separate sensorgrams and measure interactions down to milli-resonance unit (mRU), well suited for interactions with really slow off rates. Lower value compared to Biacore™ 8K and Biacore™ 8K+.
Analysis temperature (°C)	4 to 40	4 to 40	In addition, temperature-controlled compartments for samples and analysis, ensure molecule stability and allows you to measure interactions with molecules in native and active stage.
Data collection rate (Hz)	1 or 10	1 or 10	A data collection rate of 10 Hz gives the resolution of interactions and improves the accuracy of rapid on- and off-rate determinations.
Sample capacity	up to 4 × 96- or 384-well microplates	up to 12 × 96- or 384-well microplates	Increase flexibility in sample capacity and volume, with opportunity to run > 4000 interactions in one go.
Flow cell addressing	16 single or 8 pairwise	16 single or 8 pairwise	The number of flow cells indicate the analytical capacity – saving assay time, sample quantity, and sensor chips.
Unattended run time (h)	60	72	A true walk-away solution for discovery with a minimum of manual intervention, increases the throughput and analytical efficiency especially combined with the activity queuing capability.
Speed to results	*Rapid screen* 384 protein samples in 15 min *Rapid concentration* of 384 protein samples in 24 min *Binding level screen* of 384 small molecules in 4 h	*Rapid screen* 384 protein samples in 15 min *Rapid concentration* of 384 protein samples in 24 min *Binding level screen* of 384 small molecules in 4 h	Novel application tools not supported in Biacore™ 8K or Biacore™ 8K+.

Biacore™ Insight Software

Experimental design

Biacore™ Insight Software streamlines the entire SPR workflow. From run to insight, the software enables fast, intuitive run setup, data analysis, and data integration to reduce time to results regardless of user experience or instrument model.

The modular, flexible design easily switches between application specific software tools and extensions for binding, affinity, kinetics, concentration, potency, sensorgram comparison, and epitope binning to support evolving research needs.

Optional 21 CFR Part 11 compliance, support provides seamless integration into regulated workflows when required.

Predefined methods

Biacore™ Insight control software includes predefined methods with application-relevant settings for major assays. Start experiments in minutes using these methods and Biacore™ SPR consumables.

View the Biacore™ Insight software product page.

Biacore™ consumables

Cytiva provides a range of tools for reliable and reproducible data with minimal effort:

Series S sensor chips— All sensor chips are produced in a quality-controlled environment. Compatible with Biacore™ SPR system, these sensor chips support analysis of interactions from small organic molecules to viruses.
Kits, buffers, and reagents— Reduce assay development time with consistent capture of antibodies and molecules via common tags. Ready-made buffers and solutions ensure reliable results and ease of use.

What's included

Included in Biacore™ 8S and Biacore™ 8S+ SPR systems are:

Instrument, table with wheels, waste container,
2 licenses for Biacore™ Insight Software (product code 29310602),
2 licenses for Biacore™ Insight extended screening extension (product code 29310610),
2 licenses for Biacore™ Insight concentration and potency extension (29332204), and
2 licenses for Biacore™ Insight epitope binning extension (29478580)

Product specifications

Showing 4 products

29722782

Biacore 8K SPR system

1

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29722783

Biacore 8K+ SPR system

1

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On request

31194630

Biacore 8S SPR system

1

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On request

31194632

Biacore 8S+ SPR system

1

Stock on request

On request

Product availability is not guaranteed and subject to change.

Product support

Product resources

Videos

Tools

Get access to Biacore™ software downloads and manuals (registration required)
Which system is right for you? Biacore™ system selection guide compares all our SPR platforms.
Biacore™ consumables selector tool. Choose the right consumables for your system and application.
Calculators and SPR sensorgram simulation tool
App notes, articles, news and more in our SPR Solutions area

Education

Free e-learning courses. Learn the basics on how to get started with Biacore™ SPR assays and perform affinity and kinetics measurements.
Access Biacore™ sensor surface handbook (PDF, no registration required)
Fact or fiction tutorial series (videos). Is sensitivity important? Can you run serum samples in Biacore™ SPR systems? Based on our experience and tens of thousands of publications, we help you sort out fact from fiction

Services

Equipment services for Biacore™ systems. Cytiva's service solutions offer comprehensive, customizable support throughout your equipment’s lifecycle. Find a service agreement that meets your needs and desired outcome
Change control notifications (CCNs). Subscribe to CCNs for free on our Regulatory Support page.

News

Support

Accelerate your life sciences journey with our expertise and support.

Online tools

Our range of calculators, converters and selection guides will help save you time in the lab.

Contact us

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