The minimum and maximum working volumes for each system are as follows:
- X-50: 10 L to 50 L
- X-200: 40 L to 200 L
- X-500: 100 L to 500 L
- X-2000: 400 L to 2000 L
Xcellerex™ X-platform bioreactors
Scalable bioreactors for high performance, reliability and flexibility
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Xcellerex X-platform bioreactors
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Overview
The Xcellerex™ X-platform of single-use bioreactors supports working volumes from 10 L to 2000 L, allowing you to scale easily, maximize process flexibility, and reduce risk of errors. Here are the key advantages:
- Scalable
Scale-up, scale-out, and process changes are all covered with the Xcellerex™ X-platform - Whether in pilot or cGMP facilities, you’ll get the same functionality and performance from 10 L to 2000 L. - Application-ready, single-use biocontainer bags
Run fed-batch and perfusion processes with off-the-shelf, pre-optimized single-use bags. Four standard bag designs support security of supply and incorporate application-specific features and functions. - Support for high-density cell culture
Novel sparger and center, bottom-mounted impeller and drive unit provides broad power input range that can handle the highest of cell density processes. - Reducing process risk
Novel impeller base plate and bag latching mechanism ensure proper bag alignment and minimize the risk of bag failure. Innovative packaging minimizes the risk of bag damage during shipment. - Modular design
Easy on your facility space, including left or right positioning.
The Xcellerex™ X-platform bioreactors are designed with a modular approach, consisting of three separately housed components:
Bioreactor Vessel:
- Full opening door, baffles, and novel cable management solutions.
- Computational Fluid Dynamic (CFD) modeling determines the optimal placement of the drive unit, baffles, and liquid addition lines and ensures broad power input range and predictable scalability.
- The Impeller design is optimized for mixing and mass transfer of gases and cell culture media and supports a wide range of cell densities.
- The sparge design includes three main elements for oxygen mass transfer, plus an optional single element for metabolic CO2 mitigation.
- The larger Xcellerex™ X-500 and X-2000 systems feature exhaust filter assemblies accessible from ground level.
- Early foam detection and control is achieved with a novel camera technology (currently only on Xcellerex™ X-500 and X-2000).
Cabinet Assembly:
- Houses all power, gas, liquid management, and sensor components.
- Can be positioned on either side of the bioreactor for flexible arrangement.
Human Machine Interface (HMI):
- Users operate the control software (Figurate™ automation powered by PlantPAx® DCS) via the HMI, which features a 21.5 in. color touchscreen, industrial keyboard, and
- mouse designed for use in a cleanroom environment.
Xcellerex™ X-platform biocontainer bags :
Standard bag designs support security of supply and provide application-specific features and functions for use in basic applications, such as batch cultures, to more complex perfusion operations. The bags are built with industry-proven Allegro™ film and are shipped with innovative, robust packaging packaging to minimize the risk of damage.
Details on the bag configurations are listed in the data file
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