T-Series cassettes with Omega™ PES membrane, part of our Pall filtration portfolio, are designed for development, pilot, and production-scale TFF applications in diverse biological and biopharmaceutical processes.

Improved process performance. Cassettes are designed to provide optimal mass transfer to improve your process economics.
Increased safety, reliability, and reproducibility. Superior new materials of construction are durable and stable, exhibit very low extractables, and offer broad chemical compatibility.
Easy scale up for robust purification processes. Available in scalable formats with the same materials of construction from development to production-scale processes.
High flux, high selectivity, and low protein binding are achieved through the use of Omega PES membrane.
Enhanced validation. T-series cassettes surpass the latest biopharmaceutical and regulatory standards such as biological reactivity, extractables, and TOC.

Proven Omega Membrane

Omega polyethersulfone (PES) membranes offer high flux and selectivities. They have been specifically modified to minimize protein binding to the surface and interstitial structure of the membrane. This polymeric membrane is stable against biological and physical degradation due to the unique chemical properties of PES.

Omega membranes are cast on a highly porous, non-woven polyolefin support. They have an anisotropic structure, a thin skin-like top layer with a highly porous underlying support. The structure of the skin determines the porosity and permeability characteristics of the membrane and can typically be cleaned quicker and easier than membranes with a uniform, sub-micron depth structure. This membrane is compatible with acids, bases and a variety of other cleaning agents. Omega membranes are available in a wide range of nominal molecular weight cutoffs (NMWC).

The T-Series Advantage

Superior new materials of construction and improved cassette design increase process safety, reliability, reproducibility, and productivity:
The feed and permeate screen material for T-Series cassettes is made from polypropylene which is highly resistant to sodium hydroxide.
Larger feed and permeate ports provide lower pressure drops.
T-Series cassettes have been designed to provide maximum mass transfer through the membrane, resulting in faster processing times or reduced area installations compared to existing similar cassette formats.

Applications

T-Series cassettes with Omega membrane are designed for development, pilot, and production-scale TFF applications in diverse biological and biopharmaceutical processes. They are especially useful in:

• Purification and recovery of monoclonal antibodies (mAb) or recombinant proteins
• Vaccine and conjugate concentration and diafiltration
• Blood plasma fractionation and purification

Product Platforms

T-Series cassettes complement highly successful Centramate and Centrasette™ products, and have been developed following years of experience designing and optimizing our customers’ biotech and biopharmaceutical processes.

T-Series cassettes for Centramate holders are offered in scalable membrane formats with effective filtration areas (EFA) from as low as 200 cm2 (0.215 ft2) to 0.5 m2 (5.4 ft2), making them ideal for process development and small-scale production of 0.1 L to 125 L.

Centrasette™ T-Series cassettes, in combination with Centrasette™ holders, can process thousands of liters with installations incorporating hundreds of square meters of EFA.