Hydrophobic, positively charged ligands

The core of each bead is functionalized with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core. The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations. Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures using NaOH and in most cases, a solvent. 

Virus and exosome purification with Capto beads

Virus and exosome purification: harness core bead technology

Scaling up is simple

HiTrap and HiScreen columns can be connected in series for increased capacity and are convenient to use when developing an efficient and robust separation method.

Prepacked columns and other formats

Capto Core 700 is available in the following formats: 

Process development scale – prepacked

HiScreen Capto Core 700 columns – optimized for method and process development.

Lab/research scale – prepacked for manual purification

HiTrap Capto Core 700 columns – for easy use with a syringe, peristaltic pump, or chromatography system.

Lab/research scale – prepacked for automated purification and analysis

HiTrap Capto Core 700 columns – for easy use with a syringe, peristaltic pump, or chromatography system.

ReadyToProcess Capto Core 700 columns – 1 L and larger columns for clinical manufacturing that avoid the need for cleaning and cleaning validation.

Also, learn about the Capto Core 400 resin.