Capto Core 700 multimodal chromatography resin

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ID	Product Name
17548103	Capto Core 700, 1 L
17548102	Capto Core 700, 100 mL
17548101	Capto Core 700, 25 mL
17548104	Capto Core 700, 5 L

Novel core bead technology and multimodal, octylamine ligand give Capto Core 700 dual functionality. This chromatography resin has both size exclusion and binding properties.

Novel core bead technology and multimodal, octylamine ligand give Capto Core 700 dual functionality. This chromatography resin has both size exclusion and binding properties.
Novel core bead technology allows efficient capture of contaminants while target molecules are collected in the flowthrough.
Significantly improved productivity and higher flow rates compared with standard size exclusion (gel filtration) methods.
Straightforward optimization due to flowthrough chromatography and robust performance.
Convenient small-scale purification, process development, and scale-up using prepacked HiTrap and HiScreen columns.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.

Multimodal removal of contaminants

Capto Core 700 is composed of a ligand-activated core and inactive shell. The inactive shell excludes large molecules (cut off ~ Mr 700 000) from entering the core through the pores of the shell. These larger molecules are collected in the column flowthrough while smaller impurities bind to the internalized ligands.

Hydrophobic, positively charged ligands

The core of each bead is functionalized with ligands that are both hydrophobic and positively charged, resulting in a highly efficient multimodal binding of various contaminants small enough to enter the core. The multimodal ligands ensure strong binding with most impurities over a wide range of pH and salt concentrations. Bound impurities are removed from the beads by cleaning-in-place (CIP) procedures using NaOH and in most cases, a solvent.

Scaling up is simple

HiTrap and HiScreen columns can be connected in series for increased capacity and are convenient to use when developing an efficient and robust separation method.

Prepacked columns and other formats

Capto Core 700 is available in the following formats:

Process development scale – prepacked

HiScreen Capto Core 700 columns – optimized for method and process development.

Lab/research scale – prepacked for manual purification

HiTrap Capto Core 700 columns – for easy use with a syringe, peristaltic pump, or chromatography system.

Lab/research scale – prepacked for automated purification and analysis

HiTrap Capto Core 700 columns – for easy use with a syringe, peristaltic pump, or chromatography system.

ReadyToProcess Capto Core 700 columns – 1 L and larger columns for clinical manufacturing that avoid the need for cleaning and cleaning validation.

Also, learn about the Capto Core 400 resin.

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Product	Product Name	Pack size All 1 L 100 mL 25 mL 5 L	Price
17548103	Capto Core 700, 1 L	1 L	4 452.00 USD	Add to cart Get Quote In Stock Stock on request Limited stock
17548102	Capto Core 700, 100 mL	100 mL	631.00 USD	Add to cart Get Quote In Stock Stock on request Limited stock
17548101	Capto Core 700, 25 mL	25 mL	235.00 USD	Add to cart Get Quote In Stock Stock on request Limited stock
17548104	Capto Core 700, 5 L	5 L	On Request	Get Quote

Capto Core 700 multimodal chromatography resin

Multimodal removal of contaminants

Hydrophobic, positively charged ligands

Scaling up is simple

Prepacked columns and other formats

Process development scale – prepacked

Lab/research scale – prepacked for manual purification

Lab/research scale – prepacked for automated purification and analysis

ReadyToProcess Capto Core 700 columns – 1 L and larger columns for clinical manufacturing that avoid the need for cleaning and cleaning validation.

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