Wide operation window for simplified processing

The multimodal cation exchanger ligand of Capto MMC ImpRes interacts with the target molecule through multiple types of interactions, including hydrogen bonding and hydrophobic interactions.

Capto MMC ImpRes can be used for initial or final polishing steps in mAb purification processes. It can also be used for polishing of antibody fragments such as domain antibodies (DAbs).

The wide window of operation for conductivity and/or pH simplifies the downstream process, because conditioning after the protein A step can be omitted. When working with sensitive mAbs, the wide window of operation simplifies optimization of conditions.

Prepacked columns and other formats

Capto MMC ImpRes resin is available in the following formats: 

Process Development scale: prepacked

• PreDictor Capto MMC ImpRes filter plates, 96-well plates for high-throughput screening or process development.
• PreDictor MMC ImpRes RoboColumn™ units, miniaturized columns for high-throughput process development.
• HiScreen Capto MMC ImpRes columns, optimized for method and process development.

Lab scale: prepacked for manual purification

HiTrap Capto MMC ImpRes columns, for easy use with a syringe, peristaltic pump, or chromatography system.

Lab scale: prepacked for automated purification and analysis

HiTrap Capto MMC ImpRes columns, for easy use with a syringe, peristaltic pump, or chromatography system.

Process characterization: resin kits

Process Characterization Kit Capto MMC ImpRes, designed for studying the potential impact that resin ligand density might have on the process outcome.

Process scale purification: prepacked

ReadyToProcess Capto MMC ImpRes columns, 1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.