This one-needle SPR platform comes in three system configurations, Biacore™ 1K, Biacore™ 1K+ and Biacore™ 1S+, with increasing flexibility in assay design, throughput, capacity and analysis temperature.
| |
Biacore™ 1K |
Biacore™ 1K+ |
Biacore™ 1S+ |
Specification description and impact |
| Dissociation rate |
10-6 to 1 s-1 |
10-6 to 1 s-1 |
10-6 to 6 s-1 |
10-6 to 1 s-1 allows you to reliable determine molecules with very fast and slow off-rates. |
| Affinity range |
fM to mM |
fM to mM |
fM to mM |
Exceptional dynamic range allows you to measure abroad range of molecules in pure or crude samples |
| Short term noise |
Typically < 0.03 RU (RMS) |
Typically < 0.03 RU (RMS) |
Typically < 0.01 RU (RMS) |
Value < 0.01 allows you to separate sensorgrams and measure interactions down to milli-resonance unit (mRU), well suited for interactions with really slow off rates. |
| Analysis temperature |
25°C to 37°C |
25°C to 37°C |
4°C to 40°C |
Temperature controlled compartments for samples and analysis, ensure molecule stability and allows you to measure interactions with molecules in native and active stage. |
| Data collection rate |
1 or 10 Hz |
1 or 10 Hz |
1, 10 or 40 Hz |
A data collection rate of 40 Hz increases the resolution of interactions and improves the accuracy of rapid on- and off-rate determinations. |
| Sample capacity |
1 × 96- or 384-well microplate
1 × reagent rack with 21 to 43 positions |
2 × 96- or 384-well microplate
2 × reagent rack with 21 to 43 positions |
2 × 96- or 384-well microplate
2 × reagent rack with 21 to 43 positions |
Increase flexibility in sample capacity and volume, with opportunity to run of up to 768 interactions in one go. |
| Six flow cells addressing |
Individually as single flow cells or pairwise |
Individually as single flow cells, pairwise or all flow cells in series. |
Individually as single flow cells, pairwise or all flow cells in series. |
Six flow cells increase analytical capacity – saving assay time, sample quantity, and sensor chips, and enables multiplexing capability. |
| Unattended run time |
60 h |
72 h |
72 h |
Increase throughput and analytical efficiency with method queueing capabilities with a minimum of manual intervention. |
Biacore™ Insight software
Biacore™ Insight software offers unified instrument control and data evaluation, allowing straightforward transfer of methods to Biacore™ 1 series and Biacore™ 8 series SPR systems. Enhance functionality with optional application-specific software extensions and machine learning-based evaluation tools, reducing your time to results.
Visit the
Biacore™ Insight software product page here.
Biacore™ Consumables
Cytiva provides a range of tools to ensure reliable and reproducible data with minimal effort:
• Series S sensor chips: All sensor chips are produced in an quality-controlled environment. Compatible with Biacore™ SPR systems, these sensor chips support analysis of interactions from small organic molecules to viruses.
• Kits, buffers, and reagents: Reduce assay development time with consistent capture of antibodies and molecules via common tags. Ready-made buffers and solutions ensure reliable results and ease of use.
Predefined Methods
Biacore™ Insight control software includes predefined methods with application-relevant settings for major assays. Start experiments in minutes using these methods and Biacore™ SPR consumables.
What’s included
Biacore™ 1 series system packages include the instrument and 2 licenses of Biacore™ Insight Software (product code 29310602).
