Mechanistic models make it possible to create computer simulations of chromatograms. The simulations are based on physiochemical phenomena known to occur in chromatography. The benefit of a mechanistic model? You can test thousands of purification options in a few hours.
Mechanistic modeling — opportunities and challenges
Mechanistic modeling complements other process development approaches. Compared with HTPD and DoE, it allows better understanding of both the entire process and the parameters that can influence your process. And it requires fewer experiments. As a result, you can get more from your process development – more speed and more reliable results. But there’s a learning curve.