System components

The figure below shows the main components of the ÄKTA™ avant system. You can configure and customize your ÄKTA™ avant system by adding optional components.

Available in two versions

To accommodate different flow rate/pressure specifications. The versions have the same hardware setup.

Note: ÄKTA™ avant systems are not designed for use in GMP-regulated applications.

Typical process development tasks that you can perform with ÄKTA™ avant system:

• Screening chromatography resins
• Optimizing purification methods
• Intelligent column packing using preprogrammed methods
• Performing initial scale up
• Producing pure target molecules for use in preclinical studies (non-GMP)
• Testing process robustness

Free up your time with UNICORN™ control software

Control your ÄKTA™ avant system in real time with UNICORN™ software. The software is easy to use, supports productivity and data security, and enables automation. You can create methods quickly, run unattended experiments, and evaluate results efficiently.

When scaling to larger ÄKTA™ systems, you’ll use the same UNICORN™ software.

Streamlined design of experiments (DoE) and mechanistic modeling workflows

DoE

The ÄKTA™ avant system is designed for execution of DoE experimental plans. Run unattended experiments (via inlet valves, column valves, fraction collector) and execute DoE experiments at different scales.

UNICORN™ DoE integrate extension enables you to automatically integrate your DoE experimental plans to UNICORN™ scouting runs. You’ll reduce the risk of errors and save time. You can do it from any commonly used DoE software available on the market.

Mechanistic modeling

The ÄKTA™ avant system is pre-characterized for mechanistic modeling: relevant system parameters are already included in GoSilico™ software. Furthermore, for calibration runs, data can be directly transferred from UNICORN™ software into GoSilico™ software, streamlining the modeling workflow.

Chromatography resins, adsorbers, columns, and capsules

We offer an extensive range of chromatography formats that can be used with the ÄKTA™ avant system. This includes:

• Prepacked columns, such as HiTrap™, HiScreen™, or Validation columns.
• Prepacked and precharacterized f(x) columns for mechanistic modeling.
• Empty columns, such as HiScale™ or AxiChrom™ columns.
• Fiber units: HiTrap Fibro™ and HiScreen Fibro™ units.
• Adsorber units, such as XT Acrodisc™ and Mustang™ XT capsules.