HiTrap Fibro™ and HiScreen Fibro™ PrismA are protein A fiber chromatography units for rapid cycling chromatography purification of mAbs for research and process development applications. Ultrafast purification enables cycle times under 5 minutes compared to hours for resins. HiTrap Fibro™ PrismA is primarily intended for reserach use and HiScreen Fibro™ PrismA is primarily intended for early process development.

The HiTrap Fibro™ and HiScreen Fibro™ PrismA adsorbents have a protein A cellulose fiber matrix with an open pore structure where mass transfer is governed by convective flow. This structure allows high mAb binding capacities at very short residence times by using rapid cycling chromatography. This results in cycle times of minutes instead of the hours needed for resin-based chromatography. Dynamic binding capacity is ~ 30 mg IgG/mL matrix. The Fibro technology platform is designed to scale up to manufacturing scale. The units will range from research scale with a capacity of approximately 12 mg per purification cycle (0.4 mL units) to GMP compatible units that can process up to 2000 L bioreactor harvest or 10 kg mAb in one working day by cycling multiple times.