HyClone characterized fetal bovine serum (FBS) is produced using true pool technology, which minimizes bottle-to-bottle variability. This FBS product is filtered through three sequential 100 nm (0.1 µm) pore size-rated filters. Each lot of FBS is subjected to virus panel testing according to 9 CFR 113.53. HyClone characterized FBS is assayed for many components, including gamma globulin, glucose, and IgG.

Additional treatments are available: HyClone FBS heat inactivated (HI) and HyClone FBS irradiated (IR). Additional testing, including EMEA-conforming testing, is also available.

Fetal bovine serum used in cell culture

Fetal bovine serum (FBS) is frequently added to cell culture media to promote cell growth and division. Because of its high content of growth factors and other nutrients that meet the metabolic needs of eukaryotic cells, FBS serum is frequently used to grow mammalian cells including embryonic stem cells.

HyClone FBS is certified for traceability

The manufacturing processes used to create HyClone serum are traceability certified by the International Serum Industry Association (ISIA). To further support product traceability, we were an early adopter of Scientific Traceability by Oritain to prove the country of origin of premium bovine sera products from the United States, Australia, and New Zealand. Premium bovine serum samples from different regions have been analyzed, and Oritain has created a database of the unique 'Origin Fingerprint' exclusive to each country of origin.

Have Confidence in Security of Supply with Secondary Sourcing

Fetal Bovine Serum from a single origin may be limited, so it’s important to qualify FBS products from other countries to increase your security of supply. HyClone Characterized FBS from United States (US), New Zealand (NZ) and Australia (AUS) have been evaluated and tested to show equivalent performance. Read our full study.

Temperature excursions happen, both in transport and on the bench. Storage condition effects on fetal bovine serum for cell culture whitepaper shows how HyClone™ serum maintain viable cell density and cell growth and stay within specification under various temperatures and timeframes.