Single-use aseptic connectors

The manufacture of pharmaceuticals happens under current good manufacturing practices (cGMP). Based on the complexity of the processes, biomanufacturing often involves many unit operations for upstream and downstream product formulation. Processing sterile biopharmaceuticals happens in a controlled, cleanroom environment to limit the chance of contamination.

Until recently, most biomanufacturers used reusable equipment that required sterilization within the production facility, and much of the equipment used in research labs was made from stainless steel. However, the manufacture of biopharmaceutical products is rapidly shifting toward the use of disposable or single-use bioprocessing technologies.

The market for single-use bioprocessing equipment has expanded thanks to its ease of use, efficiency, and reduced risk in terms of cross-contamination.

Improving production economics primarily depends on increased manufacturing flexibility using disposable components. One piece of machinery that might affect production costs and flexibility is aseptic connections.

What are aseptic connectors?

Sterile fluid transfer between unit operations is a significant step in bioprocessing or biomanufacturing. Aseptic connectors help link various components within and between your unit operations for upstream and downstream applications.

Advantages of our ReadyMate™ disposable aseptic connectors include:

• Genderless design and cross-size connectivity for increased flexibility and reduced inventory
• Simple design for quick connections in sterile and non-sterile environments
• Various sizes to match your requirements
• Scalable from bench-top use to production
• Large inner diameter options for high-pressure and high-flow operations
• Validated closure mechanism to ensure a secure connection

ReadyMate™ aseptic single-use connectors support autoclaving and gamma radiation to provide a sterile fluid path.

Aseptic connectors vs tube welding

Aseptic connectors offer many benefits. Though many people believe that tube welding is more affordable, the costs of maintaining the welder can make disposable aseptic parts a more economical choice. This equipment is also easier to install than tube welding, saving time.

Disposable aseptic connectors come sterilized and ready to use. Conversely, tube welding requires a lengthy installation process and cure time. Single-use connectors are disposable and require no maintenance. Tube welding requires preventive maintenance of the welders for efficient operation.

Because validated aseptic connectors help maintain a sterile connection between adjoining single-use systems, they pose little or no risk of contamination. However, if users fail to conform to the manufacturer's recommendations during tube welding, they could increase the contamination risk.

Welding, when done correctly, can make a more durable connection than single-use connectors. But the training and equipment required can be more costly to maintain over time.

Either connection method can be reliable when used correctly. But our genderless aseptic connectors offer added flexibility and ease of use.

Aseptic connectors FAQs

Below are some commonly asked questions about aseptic connectors.

What role do they play in your bioprocess?

Aseptic connectors provide a simple and secure connection between unit operations for high-fluid throughput in downstream and upstream processing.

Does Cytiva offer standardized aseptic connectors and bioprocessing components?

We offer standardized single-use components to simplify your fluid management operations. ReadyMate™ connectors provide quick connection to liquid handling bags and assemblies for media and buffer operations. These aseptic connectors also easily connect to our single-use bags in bioreactors and mixers.