Aseptic filling machines
Our aseptic filling machines function as standardized, closed, robotic aseptic filling workcells for filling drug products.
Frequently asked questions
What are aseptic filling machines?
Aseptic filling is the last but crucial step in the manufacture of sterile injectable drug products.
Cytiva aseptic filling machines—including our Microcell™ Vial Filler and SA25 Aseptic Filling Workcell—are gloveless isolators that are closed and standardized for the process of filling drug products. Whether used for filling vials, syringes, or cartridges, completely closed aseptic filling machines make significant improvements to sterility assurance and drug product quality by eliminating potential risks. Learn more about the difference between a gloveless isolator and a closed robotic workcell for aseptic filling of drug products.
What is the function of an aseptic filling machine?
A closed system for reduced risk
Our aseptic filling technologies are designed to be completely closed systems. They do not have glove ports, thereby eliminating operator intervention from the aseptic process.
Built-in flexibility
Our aseptic filling systems support a flexible aseptic process for multiple dosage formats. Advanced robotics drive repeatable processes, improving drug product quality.
Standardization for fast lead and implementation times
Our standardized filling machines allow customers to reach GMP-level manufacturing processes in 6 to 15 months. That means you can add machines quickly as candidates succeed in the clinic, ultimately getting drug products to patients faster.
How do our aseptic filling machines help to ensure precision and reproducibility?
By offering high precision robotics, our aseptic filling workcells are engineered to deliver accurate and consistent fills, helping to standardize the process, ensure reproducibility, and reduce waste. Achieve the precise fill volumes you need, even for shear-sensitive liquids.
How do our aseptic filling machines help you meet sterility requirements?
The closed-system design of our aseptic filling workcells offers key advantages to achieve sterility assurance, namely preventing external contaminants from entering the filling and closing processes.
How do our aseptic filling solutions contribute to improved quality control?
Our aseptic filling machines have integrated environmental monitoring systems. Eliminating variations and helping to ensure uniform filling across vials, syringes, and cartridges enhances quality, which translates to more reliable GMP manufacturing.
Do your systems offer automation?
Yes, our aseptic filling workcells offer a user-friendly human-machine interface (HMI) and automation capabilities. An intuitive control interface empowers operators to easily enter filling parameters, monitor processes in real time, and achieve consistent results.
Can I integrate your machines into my existing manufacturing workflow?
Yes, our aseptic filling machines seamlessly integrate with Manufacturing Execution Systems (MES), allowing for streamlined workflows and data sharing—reducing lead times and improving time to market.
What applications do Cytiva aseptic filling workcells serve?
Our aseptic filling workcells play a crucial role in clinical and commercial levels of sterile drug filling. Aseptic filling processes are critical for many different types of drug products, including monoclonal antibodies, gene therapies, mRNA therapies, and others. Our workcells are agnostic and can be used for small molecules, biologics, viral vectors, mRNA, and other advanced therapy medicinal products (ATMPs). Read a testimonial about how WuXi Biologics chose a SA25 aseptic filling workcell for its clinical and small-volume commercial filling into vials, syringes, and cartridges.