Expand your application range with a flexible, high-performance surface plasmon resonance (SPR) platform for confident molecular interaction analysis.
Our Biacore™ 1 series SPR systems are designed to support versatile assay development, routine interaction studies, and streamlined workflows.
Built for use in GxP-regulated environments, this SPR machine enables reliable SPR analysis with a six flow-cell configuration that supports a broad range of interaction applications. Automated guidance, predefined methods, and flexible flow-cell control reduce operational complexity across ligand binding studies, antibody-antigen interactions, and small molecule library screening.
Designed to simplify your SPR workflow and provide high‑quality interaction data
No programming skills needed: Predefined methods help you set up and start your SPR analysis quickly.
Flexible software tools: Accelerate assay development and data evaluation for diverse applications.
Straightforward method transfer: Easily move methods across Biacore 1 series or Biacore 8 series systems for consistent workflows across teams and sites.
Faster time to insights: • Intuitive tools shorten onboarding, increase efficiency, and support rapid result generation.
Simpler data interpretation: Compile, visualize, and export data within minutes.
Novel injection and running tools: Enable multi-complex applications and support higher operational efficiency.
Maximized run efficiency Queue methods or full assays and run the system overnight or over the weekend to increase productivity.
Applications:
Epitope binning
Antibody antigen binding
Ligand binding kinetics
Small molecule library screening
General SPR analysis for molecular interactions
A flexible SPR platform that supports confident interaction characterization, efficient workflows, and a wide range of assay formats.
Compare key features of the three Biacore™ 1 series configurations:
This one-needle SPR platform comes in three system configurations, Biacore™ 1K, Biacore™ 1K+ and Biacore™ 1S+, with increasing flexibility in assay design, throughput, capacity and analysis temperature.
Biacore™ 1K
Biacore™ 1K+
Biacore™ 1S+
Specification description and impact
Dissociation rate
10-6 to 1 s-1
10-6 to 1 s-1
10-6 to 6 s-1
10-6 to 1 s-1 allows you to reliable determine molecules with very fast and slow off-rates.
Affinity range
fM to mM
fM to mM
fM to mM
Exceptional dynamic range allows you to measure abroad range of molecules in pure or crude samples
Short term noise
Typically < 0.03 RU (RMS)
Typically < 0.03 RU (RMS)
Typically < 0.01 RU (RMS)
Value < 0.01 allows you to separate sensorgrams and measure interactions down to milli-resonance unit (mRU), well suited for interactions with really slow off rates.
Analysis temperature
25°C to 37°C
25°C to 37°C
4°C to 40°C
Temperature controlled compartments for samples and analysis, ensure molecule stability and allows you to measure interactions with molecules in native and active stage.
Data collection rate
1 or 10 Hz
1 or 10 Hz
1, 10 or 40 Hz
A data collection rate of 40 Hz increases the resolution of interactions and improves the accuracy of rapid on- and off-rate determinations.
Sample capacity
1 × 96- or 384-well microplate
1 × reagent rack with 21 to 43 positions
2 × 96- or 384-well microplate
2 × reagent rack with 21 to 43 positions
2 × 96- or 384-well microplate
2 × reagent rack with 21 to 43 positions
Increase flexibility in sample capacity and volume, with opportunity to run of up to 768 interactions in one go.
Six flow cells addressing
Individually as single flow cells or pairwise
Individually as single flow cells, pairwise or all flow cells in series.
Individually as single flow cells, pairwise or all flow cells in series.
Six flow cells increase analytical capacity – saving assay time, sample quantity, and sensor chips, and enables multiplexing capability.
Unattended run time
60 h
72 h
72 h
Increase throughput and analytical efficiency with method queueing capabilities with a minimum of manual intervention.
Biacore™ Insight software
Biacore™ Insight software offers unified instrument control and data evaluation, allowing straightforward transfer of methods to Biacore™ 1 series and Biacore™ 8 series SPR systems. Enhance functionality with optional application-specific software extensions and machine learning-based evaluation tools, reducing your time to results.
Cytiva provides a range of tools to ensure reliable and reproducible data with minimal effort:
• Series S sensor chips: All sensor chips are produced in an quality-controlled environment. Compatible with Biacore™ SPR systems, these sensor chips support analysis of interactions from small organic molecules to viruses.
• Kits, buffers, and reagents: Reduce assay development time with consistent capture of antibodies and molecules via common tags. Ready-made buffers and solutions ensure reliable results and ease of use.
Predefined Methods
Biacore™ Insight control software includes predefined methods with application-relevant settings for major assays. Start experiments in minutes using these methods and Biacore™ SPR consumables.
What’s included
Biacore™ 1 series system packages include the instrument and 2 licenses of Biacore™ Insight Software (product code 29310602).
Product specifications
Showing 4 products
Biacore™ 1K+ Upgrade kit
29719933
Stock on request
On request
Biacore™ 1K SPR system
29726017
Stock on request
On request
Biacore™ 1K+ SPR system
29726018
Stock on request
On request
Biacore™ 1S+ SPR system
29726019
Stock on request
On request
Product availability is not guaranteed and subject to change.
Documents
Looking for a CoA, CoC, or other product certificates?
Free e-learning courses on SPR Learn the basics on how to get started with Biacore™ SPR assays and perform affinity and kinetics measurements.
Fact or fiction tutorial series (videos) Is sensitivity important? Can you run serum samples in Biacore™ SPR systems? Based on our experience and tens of thousands of publications, we help you sort out fact from fiction
Services
Equipment services for Biacore™ systems Our service solutions offer comprehensive, customizable support throughout your equipment’s lifecycle. Find a service agreement that meets your needs.
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