These HiTrap columns are prepacked with MabSelect PrismA protein A chromatography resin. This affinity resin in the packed column has been improved with an optimized high-flow agarose base matrix and a genetically engineered protein ligand, allowing efficient cleaning between monoclonal antibody purification runs. This allows future demands in monoclonal antibody purification to be met, including processing of many bispecific antibodies.

  • Enhanced dynamic binding capacity compared with other protein A resins.
  • Excellent alkaline stability enables efficient cleaning and sanitization using 0.5–1.0 M NaOH.
  • Convenient HiTrap format for easy connection to a syringe, peristaltic pump, or chromatography systems such as an ÄKTA system for convenient process optimization.
  • Easily measure protein A leakage using the PrismA ELISA kit specifically designed for use with MabSelect PrismA™ resins.

The enhanced alkaline stability of MabSelect PrismA also provides opportunities for more robust mAb purification using periodic counter-current chromatography. The possibility for cleaning using 1 M NaOH increases bioburden control for continuous processes, which can be exposed to days or weeks of feed harvest.

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Product Product Name Price
17549853 HiTrap MabSelect PrismA 1 x 5 mL 1 × 5 mL 877.79 USD Add to cart


17549854 HiTrap MabSelect PrismA 5 x 5 mL 5 × 5 mL 3 902.88 USD Add to cart


17549852 HiTrap MabSelect PrismA 5 x 1 mL 5 × 1 mL 856.30 USD Add to cart


17549851 HiTrap MabSelect PrismA 1 x 1 mL 1 × 1 mL 219.53 USD Add to cart


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