Tangential flow filtration for labscale
Lab-scale TFF system offers affordable, high-efficiency concentration, desalting, and purification of biomolecules
Frequently asked questions
What is the capacity of TFF systems?
Lab-scale TFF systems can handle volumes from 10 mL to thousands of liters.
Which membrane type and pore size should I choose for my application?
Our labscale TFF systems are used with Minimate™ TFF capsule filters. These capsule filters are available in different molecular weight cut off (MWCO) selection filters. Depending upon your sample, the MWCO can be selected. Several Minimate TFF capsules may be connected in parallel for increased membrane area. (For more information, contact Technical Service.) Minimate TFF capsules have the same path length and materials of construction as larger Centramate™ and Centrasette™ cassette systems used in pilot and production plants.
What are the key features of labscale TFF systems?
Minimate™ TFF systems can be used to:
- Concentrate and desalt proteins, peptides, or nucleic acids (DNA, RNA, oligonucleotides).
- Recover antibodies or recombinant proteins from clarified cell culture media.
- Process metal sensitive enzymes and molecules.
- Separate (fractionate) large from small biomolecules.
- Recover or remove viruses from solutions.
- Prepare samples prior to column chromatography.
- Concentrate samples after gel filtration.
What maintenance is required for labscale TFF systems?
Labscale Minimate™ TFF system is a cost-effective design, that's simple to clean and re-use.
What included with the labscale Minimate™ TFF system?
The system package includes a peristaltic pump, pump head, two pressure gauges, reservoir, stir plate, drip tray, and assorted fittings.