• IEX: Modeling and simulation of anion-exchange membrane chromatography for purification of Sf9 insect cell-derived virus-like particles (publication)
• IEX: Accelerating VLP purification process development (article)

• IEX: Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation (publication)
• IEX: Calibration-free inverse modeling of ion-exchange chromatography in industrial antibody purification (publication)
• IEX: Modeling of complex antibody elution behavior under high protein load densities in ion exchange chromatography using an asymmetric activity coefficient (publication)
• Prediction uncertainty assessment of chromatography models using Bayesian inference (publication)
• IEX: Optimization of an antibody polishing step (article)
• IEX: Scalability of mechanistic models for ion exchange chromatography under high load conditions (poster, FAQ)
• CIEX: Cross-scale quality assessment of a mechanistic cation exchange chromatography model (publication)
• MM: Mechanistic modeling, simulation, and optimization of mixed-mode chromatography for an antibody polishing step (publication)
• Affinity capture: Predictive scaling of fiber-based protein A capture chromatography using mechanistic modeling (publication)

• IEX: Good modeling practice for industrial chromatography - mechanistic modeling of ion exchange chromatography of a bispecific antibody (publication)

• AIEX: AAV Full/Empty Capsid Separation Using Mechanistic Modeling (article, procedure)

• Mechanistic Modeling for a Hydrophobic-Interaction Chromatography Process: Use in Vaccine Antigen Purification (article)

Hydrophobic interaction chromatography

• In silico process characterization for biopharmaceutical development following the quality by design concept (publication)
• Water on hydrophobic surfaces: Mechanistic modeling of hydrophobic interaction chromatography (publication)
• An Experimental and Modeling Combined Approach in Preparative Hydrophobic Interaction Chromatography (publication)

Flow-through processes

• Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation (publication)

Derivation of isotherm and resin parameters

• A versatile noninvasive method for adsorber quantification in batch and column chromatography based on the ionic capacity (publication)
• Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks (publication)
• UV absorption‐based inverse modeling of protein chromatography (publication)
• Isotherm model discrimination for multimodal chromatography using mechanistic models derived from high-throughput batch isotherm data (publication)

Business impact

• Do Modeling and Simulation Tools Really Benefit the Biosimilar Industry? (article)

Other:

• High‐throughput micro‐scale cultivations and chromatography modeling: Powerful tools for integrated process development (publication)
• Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography (publication)
• Simulating and optimizing preparative protein chromatography with ChromX™ (predecessor of GoSilico™ chromatography modeling software) (publication)
• A mechanistic model of ion-exchange chromatography on polymer fiber stationary phases (publication)
• Model based process optimization of an industrial chromatographic process for separation of lactoferrin from bovine milk (publication)