Minimizing RCA in adenovirus production
Minimizing RCA in adenovirus production This whitepaper describes CAP™ Ad cell, designed to minimize replication competent adenovirus (RCA) during production.
How to overcome AV manufacturing challenges
Adenovirus viral vectors are commonly used for gene therapy and vaccines. We offer a wide range of robust, scalable upstream and downstream solutions — plus a cell line engineered to minimize replication competent adenovirus (RCA) — and have the technical know-how and experience to support each process step.
Scalable process for adenovirus production
This application note describes a process for adenovirus production, from upstream cell culture to downstream purification, using modern tools and technologies.
Oncolytic adenovirus production
This collaborative study demonstrates an oncolytic AdV5 production process from cell expansion to purified virus bulk product.
Adenovirus cell line
Based on the CAP™ cell line, the CAP Ad cell line offers scalable, high-yield production of adenovirus particles ― while minimizing replication-competent adenovirus (RCA). This producer cell line is well-suited for adenovirus production for gene therapy or vaccine applications.
Process development services
Use our know-how to simplify and accelerate your development and meet your process milestones.
iCELLis™ fixed-bed bioreactors
Single-use bioreactors for industrialization of animal cell culture processes in adherent cells. Two sizes.
ÄKTA ready™ 450 Text: Single-use
Single-use chromatography system for small-scale manufacturing.
Mustang™ Q XT chromatography membrane capsules
Plug and play, scalable, reusable ion exchange membrane chromatography.
Development and manufacturing solutions
Simplify and streamline your manufacturing process with integrated solutions, speeding time to market and reducing overall cost of goods. A simplified process, using standard, equipment, qualified single-use system designs and components, lowers the risk for operator error.
-
Additional resources
- Viral vector tips
- Industrial production
- Scalable purification
- Virtual think tank
-
Related solutions
- Buffer management
- Fluid handling
-
Other gene delivery
- AAV vector
- Lentivirus