Advanced downstream bioprocess development (DEV2)

About course

In this 5-day course, you will learn advanced downstream processing design, optimization, and troubleshooting of chromatographic processes. Understand the design and optimization of critical operating parameters involved in developing a scalable, economic, and robust chromatographic process. Related topics include process hygiene, column maintenance routines, and scale-up issues. 

Students will develop a three-step chromatographic process and also optimize the process for purity, recovery, and productivity suitable for manufacturing scale.

- How strategic thinking, optimal choice, and development of chromatographic techniques secure a highly productive and economical process

- Key issues in process development

- Practicals: design and development of a scalable process for purification of a  recombinant protein

 

A basic understanding of chromatography principles and UNICORN™ software, or previous attendance of the course, Introduction to downstream techniques and bioprocessing DEV1, is recommended for this course.

Prior to attending this course, refresh your knowledge on chromatography principles with these courses: 

- Get started: UNICORN™ software for chromatography

- Regulatory: what is quality by design (QbD?)

- Get to know: DoE in protein purification

- Biomanufacturing process capability requirements

 

Course dates and locations: 

MARLBOROUGH, MA, USA

MAR 16-20, 2026 (EN)

SONGDO, SOUTH KOREA

OCT 20-23, 2026  (KR/EN)

UPPSALA, SWEDEN

MAY 18-22, 2026 (EN)

OCT 19-23, 2026 (EN)

SHANGHAI, CHINA

JUL 6-10, 2026 (CN)

NOV 9-13, 2026 (CN) 

TOKYO, JAPAN

SEP 15-17, 2026 (JP)

 

After the course, you will be able to:  

- Identify critical issues in designing a scalable chromatographic process

- Evaluate chromatographic resins and combinations of techniques suitable for industrial purification and scale-up

- Understand optimization strategies for maximizing process performance

Who should attend?

- R&D scientists and process development engineers with a basic knowledge of chromatographic techniques and UNICORN™ software used in biopharmaceutical processes

- Scientists and engineers interested in deepening their knowledge about design, optimization, and troubleshooting of chromatographic processes

Review the terms and conditions for Fast Trak™ training courses here.

Review the general course information here.

The content below will be accessible after attending the course.