Downstream bioprocessing of monoclonal antibodies (MAB1)

Course

About course

In this 4-day course, get an introduction to current challenges involved in biopharmaceutical production of mAbs. Understand general purification strategies focusing on platform processes using affinity chromatography for capture. This course will also cover polishing steps, including multimodal techniques for key contaminant removal.

In the practical session, you will define operating conditions for a human mAb process optimized for yield, productivity, and process economy. Biosimilars, analytical techniques, and manufacturing-scale considerations for purification of mAbs will also be discussed.

- Downstream processing of mAbs using chromatography

- Discussion of generic purification processes for mAb purification

- Strategies for optimization of the individual chromatography steps

- Introduction to common analytical techniques used for mAb characterization

- Discussion of manufacturing‑scale considerations related to the purification of mAbs

A basic understanding of chromatography principles is required for this course. Prior to attending this course, refresh your knowledge on chromatography principles with these courses:

- Get started: UNICORN ™ software for chromatography

- Regulatory: what is quality by design (QbD)?

- Biomanufacturing process capability requirements

- Introduction to downstream techniques and bioprocessing DEV1

Course dates and locations:

TOKYO, JAPAN

APR 21-23, 2026 (JP)

UPPSALA, SWEDEN

NOV 24-26, 2026 (EN)

After the course, you will be able to:

- Define a platform process for mAb purification suitable to the process objectives

- Develop optimization methods and understand regulatory concerns unique to mAb manufacturing processes