Capto™ adhere resin prepacked in ReadyToProcess™ columns
A multimodal anion exchange resin for intermediate purification and polishing of mAbs after protein A capture.
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Overview
These ReadyToProcess™ chromatography columns are prepacked with Capto™ adhere chromatography resin and are excellent for intermediate purification polishing and purification after protein A capture. ReadyToProcess columns are high-performance bioprocessing columns that are supplied prepacked and ready for use.
- Wide operational window of pH and conductivity.
- High capacity and productivity in flow-through mode.
- Two-step chromatographic process with protein A affinity, saves time and cuts operating costs.
- Reduced risk of cross-contamination.
- Time saving and maximized throughput by eliminating in-house packing.
About Capto adhere resins
Capto adhere is a multimodal anion exchange chromatography resin for intermediate purification and polishing of monoclonal antibodies after the Protein A capture step, giving the possibility to design a two-step chromatographic downstream process.
Enables a two-step chromatographic process
The resin is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The strong multimodal ligand gives a different selectivity compared with traditional ion exchangers. Capto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Together with a Protein A capture resin, like MabSelect PrismA, Capto adhere allows the design of a two-step chromatographic process for mAbs. For optimized performance of Capto adhere, screening and optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor 96-well filter plates.
Key benefits of ReadyToProcess columns include:
- Robust column design and verified packing methods enable consistent column performance.
- No need for column preparation, packing, and validation procedures.
- Manage timelines and minimize delays with a single supplier for resins and columns.
- Fulfills industrial demands for security of supply, robust performance, and regulatory support.
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