Finding the optimal column for your gel filtration, optimum pH for ion exchange purification, or right binding and elution buffer concentration for tagged protein purification can be a tedious task. Column Screening Kit enables automated method optimization, multistep purification, and easier column selection. Up to eight columns can be connected to the system to allow easy comparison of column performance under different running conditions. The kit enables automated column selection for optimizing both column and resins performance, as well as column switching for two-step purification protocols.